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Polymorphisms of Dioxin Receptor Complex Components and Detoxification‐Related Genes Jointly Confer Susceptibility to Advanced‐Stage Endometriosis in the Taiwanese Han Population
Author(s) -
Wu ChengHsuan,
Guo ChaoYu,
Yang JyuerGer,
Tsai HorngDer,
Chang YuJun,
Tsai PeiChien,
Hsu ChaoChin,
Kuo PaoLin
Publication year - 2012
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2011.01077.x
Subject(s) - single nucleotide polymorphism , endometriosis , genotype , biology , odds ratio , genetics , population , medicine , snp , mutant , gstp1 , gene , endocrinology , environmental health
Citation Wu C‐H, Guo C‐Y, Yang J‐G, Tsai H‐D, Chang Y‐J, Tsai P‐C, Hsu C‐C, Kuo P‐L. Polymorphisms of dioxin receptor complex components and detoxification‐related genes jointly confer susceptibility to advanced‐stage endometriosis in the Taiwanese Han population. Am J Reprod Immunol 2012; 67: 160–168 Problem To establish a multilocus model for studying the effect of dioxin receptor complex components and detoxification‐related enzymes on advanced endometriosis. Method of study Six single‐nucleotide polymorphisms (SNPs) and two deletion polymorphisms from eight genes (CYP1A1, CYP1B1, GSTM1, GSTT1, GSTP1, AhR, ARNT, and AhRR) were genotyped. Results In the single SNP analysis, GSTM1 null type and AhRR variant type were associated with a significantly increased risk of endometriosis [odds ratio (OR) = 2.38 and 2.45, respectively]. Using multiple SNPs in the logistic regression for covariates, wild‐type AhR and mutant AhRR combination was significantly higher in patients (67.8%) than in controls (48.0%) (OR = 2.76). On the other hand, mutant AhRR in combination with GSTM1 null genotype was significantly higher in patients (35.5%) than in controls (19.3%) (OR = 6.12). Conclusion Polymorphisms of dioxin receptor complex components and detoxification‐related genes jointly confer susceptibility to advanced‐stage endometriosis in the Taiwanese Han population.