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Vascular Endothelial Growth Factor Gene Polymorphisms in Spontaneously Aborted Fetuses
Author(s) -
Jeon Young Joo,
Kim Ji Hyang,
Rah HyungChul,
Kim Su Yeoun,
Yoon Tae Ki,
Choi Dong Hee,
Cha Sun Hee,
Shim Sung Han,
Kim Nam Keun
Publication year - 2011
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2011.01067.x
Subject(s) - gene , biology , fetus , vascular endothelial growth factor , genetics , pregnancy , andrology , medicine , vegf receptors , cancer research
Citation Jeon YJ, Kim JH, Rah HC, Kim SY, Yoon TK, Choi DH, Cha SH, Shim SH, Kim NK. Vascular endothelial growth factor gene polymorphisms in spontaneously aborted fetuses. Am J Reprod Immunol 2011; 66: 544–553 Problems The VEGF −1154G>A polymorphism has been reported to be a genetic risk factor for recurrent spontaneous abortion in various studies; however, these studies have focused on genetic analyses of pregnant women rather than aborted fetuses. To evaluate and confirm the association between the VEGF −1154G>A polymorphism and spontaneous abortion, we focused on the relationship between four polymorphisms in the VEGF gene (−2578C>A, −1154G>A, −634G>C, and 936C>T) and spontaneously aborted fetuses (SAFs). Method of study The subjects included 118 SAFs at <20 weeks gestation and 380 normal controls consisting of children and adults. The polymorphisms were genotyped by polymerase chain reaction–restriction fragment length polymorphism analysis. Results Spontaneously aborted fetuses exhibited significantly different frequencies of the −2578CA+AA/−634CC and −1154GA+AA/−634CC combined genotypes compared with control subjects. The frequency of the −2578A/−1154A/−634C/936C haplotype was significantly higher in SAFs. Conclusions VEGF genes −2578CA+AA/−634CC and −1154GA+AA/−634CC in the fetus are possible risk factors for spontaneous abortion.