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Immunohistochemistrical and Clinicopathological Characterization of Chronic Endometritis
Author(s) -
Kitaya Kotaro,
Yasuo Tadahiro
Publication year - 2011
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2011.01051.x
Subject(s) - endometritis , asymptomatic , endometrium , medicine , endometrial biopsy , pathological , biopsy , stromal cell , pathology , immunohistochemistry , gynecology , biology , pregnancy , genetics
Citation Kitaya K, Yasuo T. Immunohistochemistrical and clinicopathological characterization of chronic endometritis. Am J Reprod Immunol 2011; 66: 410–415 Problem Chronic endometritis is an elusive entity that is often asymptomatic and undetectable by conventional endometrial biopsy and histological examination. Using immunohistochemistry for full‐thickness endometrium, we sought for its clinicopathological features. Method of Study Two hundred and thirty‐four archival endometrial specimens obtained by hysterectomy were immunostained for the plasmacyte marker syndecan‐1 to identify chronic endometritis. Endometrial morphology was dated by the standard criteria. The immunoreactive cells were enumerated in 10 non‐overlapping endometrial stromal areas. The clinical parameters were obtained from the medical charts. Results Chronic endometritis was identified in 11.1% of the samples examined. Its occurrence was similar between the proliferative phase and secretory phase. A total of 23.1% of the cases were asymptomatic. Stromal plasmacyte infiltration and morphological delay were more prominent in symptomatic chronic endometritis than in asymptomatic counterpart. Conclusions Chronic endometritis is a common gynecological pathological condition and more often asymptomatic than ever expected. There was no menstrual cycle‐dependent fluctuation in its occurrence.