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Uterine Regulatory T cells, IL‐10 and Hypertension
Author(s) -
Nevers Tania,
Kalkunte Satyan,
Sharma Surendra
Publication year - 2011
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2011.01040.x
Subject(s) - immune system , decidua , pregnancy , immune tolerance , population , immunology , biology , homeostasis , regulatory t cell , cytokine , t cell , fetus , medicine , microbiology and biotechnology , placenta , il 2 receptor , genetics , environmental health
Citation Nevers T, Kalkunte S, Sharma S. Uterine Regulatory T Cells, IL‐10 and hypertension. Am J Reprod Immunol 2011; 66 (Suppl. 1): 88–92 Problem Regulatory T cells (T reg ) are a vital immune cellular population at the maternal–fetal interface. They are likely to aid in immune tolerance by dampening the harmful effects of other immune cellular populations through cell–cell‐mediated interactions as well as by producing IL‐10 and TGF‐β. In addition to the anti‐inflammatory properties, IL‐10 has emerged as an important vascular cytokine choreographing endovascular interactions and angiogenesis and regulates hypertension. Method of study Review of innovative concepts to understand the temporal role of T regs in both mouse and human pregnancy, particularly whether uterine T reg play a potential role in regulating vascular homeostasis and blood flow during pregnancy. Results T reg guard immune tolerance, getting cytotoxically activated under certain conditions, leading to adverse pregnancy outcome. Conclusion Despite increasing evidence of T reg tissue‐specific expansion and functional plasticity, their role in vascular activity, pre‐eclampsia or gestational diabetes is obscure and needs closer investigation to delineate its role later during pregnancy.