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Urotensin‐II 143 G/A Polymorphism is not Associated with the Risk of Preeclampsia in Korean Women
Author(s) -
Na Sunghoon,
Shim JaeYoon,
Jung BokKyung,
Won HyeSung,
Lee Pil Ryang,
Kim Ahm
Publication year - 2011
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2011.01022.x
Subject(s) - preeclampsia , urotensin ii , polymorphism (computer science) , medicine , gynecology , endocrinology , biology , obstetrics , genetics , pregnancy , genotype , gene , receptor
Citation Na S, Shim J‐Yoon, Jung B‐Kyung, Won H‐Sung, Lee PRyang, Kim A. Urotensin‐II 143 G/A polymorphism is not associated with the risk of preeclampsia in Korean women. Am J Reprod Immunol 2011; 66: 423–427 Problem Urotensin‐II (UTS‐II) may be associated with preeclampsia. We therefore assessed whether the UTS‐II 143 G/A polymorphism is associated with preeclampsia in Korean women. Method of study This prospective case–control study enrolled 109 patients with preeclampsia and 144 healthy pregnant controls, all of whom were genotyped for the UTS‐II 143 G/A polymorphism using the real‐time TaqMan SNP Genotyping Assay. Results There was no significant difference in the distribution of the 143 G/A polymorphism or the frequency of the 143 A allele between women with preeclampsia and controls. In a dominant model, carriers of the A allele were not significantly more prevalent in the preeclamptic (53.2%) than in the control (60.4%) group. In addition, subgroup analysis showed no significant difference in genotype distribution or allelic frequency of the 143 G/A polymorphism between women with mild or severe preeclampsia and controls. Conclusion In Korean women, the common UTS‐II 143 G/A polymorphism is unlikely to have an association with the risk of preeclampsia.