Premium
Cervico‐Vaginal Tissue Ex Vivo as a Model to Study Early Events in HIV‐1 Infection
Author(s) -
Merbah Melanie,
Introini Andrea,
Fitzgerald Wendy,
Grivel JeanCharles,
Lisco Andrea,
Vanpouille Christophe,
Margolis Leonid
Publication year - 2011
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2010.00967.x
Subject(s) - ex vivo , human immunodeficiency virus (hiv) , transmission (telecommunications) , in vivo , biology , genital tract , vagina , immunology , cell , virology , physiology , anatomy , genetics , electrical engineering , engineering
Citation Merbah M, Introini A, Fitzgerald W, Grivel J‐C, Lisco A, Vanpouille C, Margolis L. Cervico‐vaginal tissue ex vivo as a model to study early events in HIV‐1 infection. Am J Reprod Immunol 2011; 65: 268–278 Vaginal intercourse remains the most prevalent route of infection of women. In spite of many efforts, the detailed mechanisms of HIV‐1 transmission in the female lower genital tract remain largely unknown. With all the obvious restrictions on studying these mechanisms in humans, their understanding depends on the development of adequate experimental models. Isolated cell cultures do not faithfully reproduce important aspects of cell–cell interactions in living tissues and tissue responses to pathogens. Explants and other types of ex vivo tissue models serve as a bridge between cell culture and tissues in vivo . Herein, we discuss various cervico‐vaginal tissue models and their use in studying HIV vaginal transmission and consider future directions of such studies.