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The Power of Observation
American Journal Of Reproductive ImmunologyPeer ReviewedClark David A.2011Journals
Citation
Clark DA. The power of observation. Am J Reprod Immunol 2011; 66: 71–75 Problem In the golden age of evidence‐based medicine, how should one view the cohort‐controlled study of IVIG + anti‐TNF‐α (Humira) in recurrent in vitro fertilization (IVF) failure patients with an elevated Th1/Th2 cytokine production ratio. Method Critical analysis of the nature of evidence for causation. Results A better delivery rate and a live birth rate per embryo approaching the estimated maximum possible in patients whose elevated Th1/Th2 ratio corrected to normal compared to those with an incomplete correction is a strong argument for causation. A maximal improvement when treatment was given 61–120 days before embryo transfer suggests a possible mechanism via improving the physiology during follicle development. Conclusion Independent replication to verify results would augment power.
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