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The Role of the Foreskin in Male Circumcision: An Evidence‐Based Review
Author(s) -
Dinh Minh H.,
Fahrbach Kelly M.,
Hope Thomas J.
Publication year - 2011
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2010.00934.x
Subject(s) - foreskin , male circumcision , transmission (telecommunications) , human immunodeficiency virus (hiv) , sex organ , sexual transmission , affect (linguistics) , medicine , biology , virology , psychology , population , environmental health , health services , communication , genetics , computer science , microbicide , cell culture , telecommunications
Citation Dinh MH, Fahrbach KM, Hope TJ. The role of the foreskin in male circumcision: an evidence‐based review.
Am J Reprod Immunol 2011; 65: 279–283 HIV sexual transmission via the male genital tract remains poorly defined. Male circumcision was shown to reduce female‐to‐male transmission in Africa, providing a clue that the foreskin plays a role in the route of transmission. Scientific data in four categories relating to how the foreskin might affect HIV transmission is summarized: (i) surface area, (ii) microbiologic environment, (iii) HIV‐1‐susceptible cells, and (iv) tissue structure. The relative contribution of each of these areas is yet unknown, and further studies will be crucial in understanding how male circumcision affects HIV transmission in men.