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Pathophysiological Roles of Chemokines in Human Reproduction: An Overview
Author(s) -
Kitaya Kotaro,
Yamada Hisao
Publication year - 2011
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2010.00928.x
Subject(s) - chemokine , biology , immunology , human reproduction , microbiology and biotechnology , inflammation , anatomy
Citation Kitaya K, Yamada H. Pathophysiological Roles of Chemokines in Human Reproduction: An Overview. Am J Reprod Immunol 2011; 65: 449–459 Chemokines are a group of small cytokines that have an ability to induce leukocyte migration. Chemokines exert their functions by binding and activating specific G protein‐coupled receptors. Studies have unveiled pleiotropic bioactivities of chemokines in various phenomena ranging from immunomodulation, embryogenesis, and homeostasis to pathogenesis. In the mammalian reproductive system, chemokines unexceptionally serve in multimodal events that are closely associated with establishment, maintenance, and deterioration of fecundity. The aim of this review is to update the knowledge on chemokines in male and female genital organs, with a focus on their potential pathophysiological roles in human reproduction.