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Immunologic Characteristics of Preeclampsia, a Comprehensive Review
Author(s) -
Ahn Hyunkyong,
Park Jooncheol,
GilmanSachs Alice,
KwakKim Joanne
Publication year - 2011
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2010.00913.x
Subject(s) - preeclampsia , immunology , context (archaeology) , pathogenesis , immune system , acquired immune system , pregnancy , immunity , medicine , innate immune system , humoral immunity , biology , paleontology , genetics
Citation
Ahn H, Park J, Gilman‐Sachs A, Kwak‐Kim J. Immunologic characteristics of preeclampsia, a comprehensive review. Am J Reprod Immunol 2011; 65: 377–394 Preeclampsia (PE) remains a leading cause of maternal and fetal morbidity and mortality. Despite decades of intense research on the problem, there is no early pregnancy screening test to recognize those at risk. Recently, altered immune responses have been suspected to be involved in preeclampsia pathogenesis, which may involve the inflammatory context in which an immune response is mounted. In this review, the immunologic pathogenesis of the PE is reviewed in context of innate and adaptive immunity (both cellular, i.e., T and NK cells, and humoral immunity) in relation to thrombophilic conditions.