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Association of Peroxisome Proliferator‐Activated Receptor‐Gamma 2 Pro12Ala Polymorphism with Advanced‐Stage Endometriosis
Author(s) -
Hwang Kyu Ri,
Choi Young Min,
Kim Jong Mee,
Lee Gyoung Hoon,
Kim Jin Ju,
Chae Soo Jin,
Moon Shin Yong
Publication year - 2010
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2010.00882.x
Subject(s) - endometriosis , restriction fragment length polymorphism , allele , medicine , allele frequency , peroxisome proliferator activated receptor , polymorphism (computer science) , population , biology , genotype , endocrinology , oncology , receptor , gastroenterology , gene , genetics , environmental health
Citation Hwang KR, Choi YM, Kim JM, Lee GH, Kim JJ, Chae SJ, Moon SY. Association of peroxisome proliferator‐activated receptor‐gamma 2 Pro12Ala polymorphism with advanced‐stage endometriosis. Am J Reprod Immunol 2010 Problem To investigate whether the peroxisome proliferator‐activated receptor (PPAR)‐γ2 Pro12Ala polymorphism is associated with a risk of advanced‐stage endometriosis in a Korean population. Methods of study Case–control study in a collective of 446 patients and 427 controls. The Pro12Ala polymorphism of PPAR‐γ2 gene was genotyped using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. Results The distribution of the PPAR‐γ2 Pro12Ala polymorphism was different between the advanced‐stage endometriosis group and the control group (non‐CC rates were 5.2% for patients with advanced endometriosis and 10.1% for the control group, respectively, P = 0.006). The frequency for the Ala‐12 allele variant was significantly lower in patients with advanced stage of endometriosis (2.7%) than in the control group (5.3%) ( P = 0.006). Conclusion These findings suggest that the PPAR‐γ2 Pro12Ala polymorphism is associated with advanced‐stage endometriosis in the Korean population. Unlike results from other studies reported so far, the Ala‐12 allele may have protective effects against advanced‐stage endometriosis in the Korean population.