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Accumulation of IL‐17‐Positive Cells in Decidua of Inevitable Abortion Cases
Author(s) -
Nakashima Akitoshi,
Ito Mika,
Shima Tomoko,
Bac Nguyen Duy,
Hidaka Takao,
Saito Shigeru
Publication year - 2010
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2010.00812.x
Subject(s) - decidua , abortion , medicine , pregnancy , cd8 , flow cytometry , immunohistochemistry , andrology , immunology , fetus , immune system , biology , placenta , genetics
Citation Nakashima A, Ito M, Shima T, Bac ND, Hidaka T, Saito S. Accumulation of IL‐17‐positive cells in decidua of inevitable abortion cases. Am J Reprod Immunol 2010 Problem Th17 cells, a new subset of helper T cells, have been focused on as a producer pro‐inflammatory cytokines. It is, however, still unknown how Th17 cells affect pregnancy outcome. We investigated the expression of IL‐17‐producing cells in human spontaneous abortion. Method of study IL‐17 expression was analyzed in decidual tissues among normal pregnancy, missed abortion, and inevitable abortion cases by immunohistochemistry and flow cytometry. Results IL‐17 + cells were accumulated in decidua and were detected in decidual CD4 + T cells and few decidual CD8 + T cells in spontaneous abortion cases. The number of decidual IL‐17 + cells in inevitable abortion cases involving active genital bleeding was significantly higher than that in normal pregnancy cases ( P < 0.05). On the other hand, there were no significant differences in the numbers of decidual IL‐17 + cells between missed abortion cases and normal pregnancy subjects. Furthermore, the number of IL‐17 + cells was positively correlated with the number of neutrophils in spontaneous abortion cases. Conclusion IL‐17 + cells might be involved in the induction of inflammation in the late stage of abortion, but not in the early stage of abortion.