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REVIEW ARTICLE: Toll‐Like Receptor Signaling and Pre‐Eclampsia
Author(s) -
Xie Fang,
Turvey Stuart E.,
Williams Michelle A.,
Mor Gil,
Von Dadelszen Peter
Publication year - 2010
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2009.00745.x
Subject(s) - innate immune system , eclampsia , biology , immunology , inflammation , immune system , signal transduction , receptor , toll like receptor , pathogen associated molecular pattern , pattern recognition receptor , microbiology and biotechnology , pregnancy , genetics
Systemic inflammation and abnormal/poor placentation represent hallmarks of pre‐eclampsia. Accumulating evidence suggests that infectious agents might increase the risk of pre‐eclampsia; the innate immune defense mechanisms may interact with pro‐inflammatory pathways, and contribute to the development of pre‐eclampsia. The evidence for this has been supported by indirect epidemiologic and clinical studies, as well as by some direct support from experimental studies. Recent data directly implicate signaling by Toll‐like receptors in the pathogenesis of pre‐eclampsia, and establish a crucial link between pre‐eclampsia and defense against both foreign pathogens and endogenously generated inflammatory ligands. Here, we review the rapid progress in this field, which has improved our understanding of the interplay between pathogen invasion, innate immune defense mechanisms, and pre‐eclampsia.