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ORIGINAL ARTICLE: Serum IL‐6 Level May Have Role in the Pathophysiology of Unexplained Infertility
Author(s) -
Demir Bulent,
Guven Suleyman,
Guvendag Guven Emine Seda,
Atamer Yildiz,
Gul Talip
Publication year - 2009
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2009.00734.x
Subject(s) - pathophysiology , unexplained infertility , infertility , medicine , physiology , immunology , andrology , gynecology , pregnancy , biology , genetics
Problem The aim of this study was to compare the serum levels of interleukin (IL)‐6 of women with unexplained infertility with fertile subjects. Method of study Serum IL‐6, and tumor necrosis factor‐α (TNF‐α) levels of 45 infertile and 44 fertile women on day 3 of menstrual cycle were assessed and compared for this prospective controlled study. Results The mean serum IL‐6 level was significantly higher in women with unexplained infertility, compared with fertile women (5.71 ± 1.81 and 4.31 ± 1.79, P < 0.001, Student’s t ‐test). There was no significant difference in TNF‐α level among the groups. Conclusion Significant difference in serum IL‐6 levels between unexplained infertile and fertile women suggests that this cytokine may be involved in pathophysiology of unexplained infertility.