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ORIGINAL ARTICLE: Allergic Women have Reduced sHLA‐G Plasma Levels at Delivery
Author(s) -
Rizzo Roberta,
Stignani Marina,
Amoudruz Petra,
Nilsson Caroline,
Melchiorri Loredana,
Baricordi Olavio,
SverremarkEkström Eva
Publication year - 2009
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2009.00703.x
Subject(s) - pregnancy , medicine , immunology , allergic inflammation , hla g , gene isoform , human leukocyte antigen , allergy , antigen , chemistry , biology , biochemistry , genetics , gene
Problem HLA‐G antigen maintains a tolerogenic condition at the foeto‐maternal interface, counteracts inflammation in autoimmune diseases and soluble HLA‐G (sHLA‐G) levels decrease in allergic‐asthmatics. Taking into consideration these findings, we analyzed if sHLA‐G and interleukin‐10 (IL‐10) could be influenced by pregnancy and labour in allergic and non‐allergic women. Method of study sHLA‐G isoforms and IL‐10 levels were determined in the plasma samples of 43 women (15 non‐allergic, 28 allergic) during third trimester, at delivery and 2 years after pregnancy by immunoenzymatic assays. Results A significant increase in sHLA‐G and IL‐10 levels was documented at delivery in both allergic and non‐allergic women. Allergic women showed lower sHLA‐G concentrations. sHLA‐G1 was evidenced as the predominant plasma isoform. Conclusion The data showed increased sHLA‐G and IL‐10 concentrations at delivery, regardless of the allergic status. The sHLA‐G1 isoform is mainly responsible for the increased sHLA‐G levels at delivery.