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SHORT COMMUNICATION: Interleukin‐17 Increased Progesterone Secretion by JEG‐3 Human Choriocarcinoma Cells
Author(s) -
Pongcharoen Sutatip,
Supalap Kwansuda
Publication year - 2009
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2009.00693.x
Subject(s) - human chorionic gonadotropin , secretion , choriocarcinoma , endocrinology , medicine , trophoblast , cytokine , gonadotropin , progesterone receptor , interleukin , biology , chorioepithelioma , chemistry , hormone , placenta , pregnancy , fetus , cancer , genetics , estrogen receptor , breast cancer
Problem JEG‐3 choriocarcinoma cell line has previously been reported to express a receptor for interleukin (IL)‐17. The involvement of IL‐17 in the production of progesterone and human chorionic gonadotropin by placental trophoblast has not been investigated. Method of study The present study investigated the in vitro effect of IL‐17 on progesterone and human chorionic gonadotropin (hCG) secretion by JEG‐3 cells. Both hormones were quantified using enzyme‐linked immunosorbent assays. Results The results showed that IL‐17 significantly increased progesterone secretion at 6 ( P < 0.001) and 24 ( P < 0.01) hr, while this cytokine had no effect on hCG secretion. Conclusion Interleukin‐17 may regulate the function of JEG‐3 cells through increased progesterone secretion.