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ORIGINAL ARTICLE: Glycation Endproducts, Soluble Receptor for Advanced Glycation Endproducts and Cytokines in Diabetic and Non‐diabetic Pregnancies
Author(s) -
PertyńskaMarczewska Magdalena,
Głowacka Ewa,
Sobczak Małgorzata,
Cypryk Katarzyna,
Wilczyński Jan
Publication year - 2009
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2008.00679.x
Subject(s) - glycation , medicine , endocrinology , diabetes mellitus , receptor , immunology , cancer research
Problem Cytokines, advanced glycation end products (AGEs), and their receptor RAGE have been recently suggested to play a role in human pregnancy. In this study, we sought to determine the alterations of plasma AGEs, soluble RAGE (sRAGE), and proinflammatory cytokines in normal pregnancies and those complicated with type 1 diabetes mellitus. Method of study These parameters were measured in samples from healthy non‐pregnant (C), diabetic non‐pregnant (D), healthy pregnant (HP), and pregnant diabetic (DP) women. Results In the first trimester, DP showed lower sRAGE and higher AGEs compared to HP. In the DP group, significant negative correlations were seen between TNF‐α and lipopolysaccharide (LPS)‐stimulated ΙL‐6 in the first trimester and sRAGE in the third trimester. LPS‐stimulated IL‐12 was positively correlated with levels of AGEs in the third trimester. Conclusion We detected several differences in the levels of AGEs, sRAGE, and proinflammatory cytokines between euglycemic and diabetic pregnancies.