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ORIGINAL ARTICLE: IL‐6 as a Regulatory Factor of the Humoral Response During Pregnancy
Author(s) -
Dubinsky Valeria,
Junovich Gisela,
Gentile Teresa,
Gutiérrez Gabriela
Publication year - 2008
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2008.00614.x
Subject(s) - abortion , pregnancy , blocking antibody , antibody , immunology , medicine , interleukin 6 , endocrinology , biology , cytokine , genetics
Problem Regulatory factors seem to be essential to achieve transition from implantation window to placental vascularization. A novel function of interleukin (IL)‐6 in the promotion of Th2 differentiation and inhibition of Th1 polarization has been demonstrated. Considering that Th2 response promotes antibody synthesis, we postulate that IL‐6 could be modulating the quality of this response during pregnancy by increasing the proportion of blocking asymmetric antibodies. Method of study We investigated expression of blocking‐asymmetric‐IgG during pregnancy of CBA/J × DBA/2 abortion model treated with IL‐6, with regards to CBA/J × BALB/c. We also determined asymmetric‐IgG production in IL‐6‐deficient pregnant mice. Results We found that IL‐6 treatment increased asymmetric‐IgG in multiparous placentas from abortion combination whereas diminished abortion rate. Moreover, asymmetric‐IgG proportion was diminished in sera from IL‐6‐deficient pregnant mice. Conclusion Modulation of asymmetric antibody synthesis could be another mechanism implicated in the beneficial effect of IL‐6 in prevention of murine recurrent abortion.