Premium
ORIGINAL ARTICLE: How Valuable is Measurement of Peripheral Blood Natural Killer Cells at the Time of Abortion?
Author(s) -
Paparistidis Nikolaos,
Papadopoulou Chryssa,
Chioti Athanassia,
Papaioannou Demetrios,
Tsekoura Christina,
Keramitsoglou Theodora,
KontopoulouAntonopoulou Virginia,
Agapitos Emmanouel,
Balafoutas Christos,
VarlaLeftherioti Marighoula
Publication year - 2008
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2007.00547.x
Subject(s) - miscarriage , abortion , natural killer cell , immune system , curettage , pregnancy , medicine , cd16 , recurrent miscarriage , decidua , etiology , peripheral blood , immunology , obstetrics , andrology , gynecology , fetus , biology , pathology , placenta , cytotoxic t cell , biochemistry , cd8 , genetics , cd3 , in vitro
Problem Increased peripheral blood natural killer (NK) cells are associated to immune‐mediated abortion, but their diagnostic value when measured at the time of miscarriage is unknown. Method of study In women with therapeutic (A = 79) or elective (C = 34) pregnancy termination, the NK‐cell percentage was measured before and 5 days after curettage. Additionally, immune‐mediated lesions (scored 0–3) and CD56 + and CD16 + decidual ΝΚs (scored 1–3) were detected on the abortion material. Results Aborters differed from controls in histological scores ( P = 0.000) and in NK percentage (>12%) only in the measurement 5 days after the operation ( P = 0.038). In comparison to histological lesions, NK measurement was found to have sensitivity 70%, specificity 73.68%, positive prognostic value 89.39% and negative prognostic value 43.75%. Conclusion An Increased NK‐cell percentage 5 days after the pregnancy termination could be a marker of immune aetiology of miscarriage, as the probability of an aborter with NK >12% to have an immune‐mediated abortion is almost 90%.