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Relationship Between Human Tumor‐Associated Antigen RCAS1 and Gestational Diabetes Mellitus
Author(s) -
Tskitishvili Ekaterine,
Komoto Yoshiko,
Kinugasa Yukiko,
Kanagawa Takeshi,
Song Mihyon,
Mimura Kazuya,
Tomimatsu Takuji,
Kimura Tadashi,
Shimoya Koichiro
Publication year - 2007
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2007.00528.x
Subject(s) - gestational diabetes , placenta , cord blood , immunohistochemistry , medicine , gestation , pregnancy , antigen , endocrinology , diabetes mellitus , immune system , cancer antigen , fetus , cancer , biology , immunology , genetics
Problem The human tumor‐associated receptor‐binding cancer antigen expressed on SiSo cells (RCAS1) is considered to play a role in the inhibition of the maternal immune response during pregnancy. The aim of our study was to investigate the expression of RCAS1 protein in the placenta and to compare its concentration in maternal and cord blood sera between normal pregnancies and pregnancies complicated by gestational diabetes mellitus (GDM). Method of study Samples were obtained from women with GDM ( n = 8), women with type 1 DM ( n = 5), and healthy term controls ( n = 27) after delivery. Placentas were studied by immunohistochemistry, and real‐time polymerase chain reaction. For assessment of RCAS1 concentrations in maternal and cord blood sera, enzyme‐linked immunosorbent assay was performed. Results The RCAS1 protein mRNA expression in the placentas of patients with GDM was significantly lower than that in the controls ( P = 0.005). The maternal blood RCAS1 protein concentration of the GDM cases was also significantly lower than that in the controls ( P = 0.0411), whereas the cord blood RCAS1 protein concentration was significantly higher in the GDM and type 1 DM groups than in the controls ( P = 0.0311 and P = 0.0192, respectively). Conclusion The present results suggest that RCAS1 protein might have an important role in the development of GDM.