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Polymorphisms in the Interleukin‐12/18 Genes and Recurrent Spontaneous Abortion
Author(s) -
Ostojić Saša,
Volk Marija,
Medica Igor,
Kapović Miljenko,
MedenVrtovec Helena,
Peterlin Borut
Publication year - 2007
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2007.00501.x
Subject(s) - genotype , interleukin 18 , abortion , interleukin 12 , haplotype , gene , interleukin , case control study , polymorphism (computer science) , medicine , immunology , cytokine , endocrinology , gastroenterology , biology , genetics , pregnancy , cytotoxic t cell , in vitro
Problem Interleukin (IL) IL‐12/IL‐18 are involved in uterine NK cells control of uterine vascular development. Polymorphisms in the IL‐12/IL‐18 genes could modify the cytokine balance, which might result in an increased susceptibility to recurrent spontaneous abortion (RSA). Method of Study A case–control study was conducted to determine the association between the IL12 (I/D) and IL18 ( −607C>A , −137G>C ) gene polymorphisms and the risk of RSA in 125 women with RSA and in 136 controls. Results The frequencies of DD, ID, II for IL‐12 were, 25.6%, 52.8% and 21.6% respectively, in patients versus 21.3%, 51.5% and 27.2% respectively in controls; the frequencies of CC, CA, AA genotypes for IL‐18 (−607) were, 34.4%, 54.4% and 11.2% respectively in patients versus 30.1%, 58.1% and 11.8% respectively in controls; the frequencies of GG, GC, CC genotypes for IL‐18(−137) were 47.2%, 43.2% and 9.6% respectively in patients and 45.6%, 46.3% and 8.1% respectively in controls. Conclusion IL‐12B and IL‐18 promoter gene polymorphisms were not associated with RSA in our women.