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Synergistic effect of interleukin‐6 promoter (IL6 −634C/G) and intercellular adhesion molecule‐1 (ICAM‐1 469K/E) gene polymorphisms on the risk of endometriosis in Japanese women
Author(s) -
Kitawaki Jo,
Kiyomizu Miyo,
Obayashi Hiroshi,
Ohta Mitsuhiro,
Ishihara Hiroaki,
Hasegawa Goji,
Nakamura Naoto,
Yoshikawa Toshikazu,
Honjo Hideo
Publication year - 2006
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2006.00426.x
Subject(s) - endometriosis , genotype , icam 1 , allele , medicine , intercellular adhesion molecule 1 , genetic predisposition , gene polymorphism , immunology , endocrinology , gene , cell adhesion molecule , genetics , biology , disease
Problem Endometriosis is an immune‐related, chronic inflammatory disease with a polygenic predisposition. The aim of this study was to investigate whether the interleukin‐6 (IL‐6) gene promoter region polymorphism (−634C/G) and the intercellular adhesion molecule‐1 (ICAM‐1) gene 469K/E polymorphism are responsible in part for the genetic susceptibility to endometriosis. Methods of study The IL‐6 −634C/G and ICAM‐1 469K/E genotypes were determined in 202 patients with endometriosis and 236 control women by polymerase chain reaction‐restriction fragment length polymorphism. Results There were no differences in the IL‐6 −634C/G or the ICAM‐1 469K/E genotypes and allele frequencies between control women and endometriosis patients collectively, or between control women and each clinical subgroup of endometriosis patients. Interestingly, the frequency of ICAM‐1 EE homozygotes who concomitantly carried the IL‐6 −634G allele was significantly higher in patients with endometriosis ( χ 2 = 6.458, P = 0.0396, d.f. = 2). Conclusion Our results suggest that the IL‐6 −634C/G and ICAM‐1 469K/E polymorphisms synergistically affect the susceptibility for endometriosis in the Japanese population.