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Tumor‐infiltrating lymphocytes contain higher proportion of FOXP3+ T lymphocytes from cervical cancer than that from cervical intraepithelial zneoplasm
Author(s) -
Kuo TY,
Ho HN
Publication year - 2006
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2006.00383_15.x
Subject(s) - foxp3 , cervical cancer , cervical intraepithelial neoplasia , lymph node , immune system , immunofluorescence , tumor infiltrating lymphocytes , cancer research , pathology , biology , cancer , medicine , immunology , antibody , immunotherapy
Cervical cancer (CC) is preceded by well‐defined changes in the epithelium known as cervical intraepithelial neoplasm (CIN). Our previous studies have revealed that the subpopulations and functions of tumor‐ infiltrating lymphocytes (TIL) from CC are altered. Dysfunction of the host immune system in cancer patients can be due to a number of reasons including the inhibitory functions of regulatory T (Treg) cells. FOXP3 has been shown to be a master control gene for the development and function of CD4 + CD25 + Treg cells. To characterize the functional role of Treg cells in progress of CC, we compared samples from four groups: CIN 2, CIN3, CC with and without tumor draining lymph node. By using the immunofluorescence staining and confocal‐based image quantitative analysis in paraffin‐embedded tissue sections, excess in the presence of FOXP3 + cells is observed from CC compared to that from CIN2/3. The significant difference of FOXP3 + cells expression level between CIN and CC indicate that the Treg might play an important role in the progression of CC.