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In Vivo Correlation between IL‐1β Concentration in Uterine Fluid and Integrin Expression Pattern in Infertile Women
Author(s) -
Mikolajczyk Mateusz,
Wirstlein Przemyslaw,
Szymanowski Krzysztof,
Skrzypczak Jana
Publication year - 2006
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2005.00346.x
Subject(s) - endometrium , immunohistochemistry , integrin , andrology , in vivo , correlation , endocrinology , biology , medicine , receptor , microbiology and biotechnology , geometry , mathematics
Problem To evaluate the possible correlation between interleukin‐1beta (IL‐1 β ) and integrin expression. Method of study Endometrium and uterine fluid from 77 infertile women and 24 fertile, healthy control were studied with immunohistochemistry and enzyme‐linked immunosorbent assay for the presence of IL‐1 β and integrin alphaVbeta3 and alpha4beta1 expression. Results Highest expression of alphaVbeta3 was found in epithelium and glands in endometria from fertile women. There was no positive correlation between IL‐1 β and integrin expression pattern. Conclusion This study confirms the importance of alphaVbeta3 as molecular marker of receptive phase. Also supports the views that synchrony in development of endometrium is necessary for successful nidation. There was however, contrary to results of previous in vitro studies, no positive correlation between IL‐1 β and endometrial integrin patter expression.