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The Factor V Leiden and the G20210A Prothrombin Gene Mutations are Rare in Women with Fetal Death
Author(s) -
Sullivan Amy E.,
Nelson Lesa,
Rice Juhree A.,
Flint Porter T.,
Ware Branch D.,
Silver Robert M.
Publication year - 2005
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2005.00277.x
Subject(s) - factor v leiden , fetus , fetal death , medicine , prothrombin g20210a , conceptus , factor v , obstetrics , population , gestation , pregnancy , genetics , biology , venous thrombosis , thrombosis , environmental health
Problem: To determine if there is an association between two commonly inherited thrombophilias, the factor V Leiden and the G20210A prothrombin mutations, and fetal death. Method of study: We used a case–control study design to compare the frequencies of these mutations in women with fetal death and controls. Fetal death was the intrauterine death of the conceptus ≥10 weeks gestation. Controls had one live birth, no miscarriages, and no fetal death. Results were compared using chi square analysis. Results: One hundred and seventy‐five cases and controls were identified. There were 4.6% of cases and 3.8% of controls heterozygous for the factor V Leiden mutation (NS), and 1.3% of cases and 1.7% of controls heterozygous for the prothrombin mutation (NS). Conclusion: In our population, neither the factor V Leiden nor the G20210A prothrombin mutations are associated with fetal death. Further evidence is required before routine screening for these mutations can be recommended.