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Lymphocyte Sub‐populations in Gestational Diabetes
Author(s) -
Mahmoud Fadia,
Abul Habib,
Omu Alexander,
Haines David
Publication year - 2005
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2004.00241.x
Subject(s) - medicine , gestational diabetes , il 2 receptor , immunosuppression , cohort , cd8 , pregnancy , insulin , immune system , flow cytometry , endocrinology , diabetes mellitus , peripheral blood lymphocyte , gestation , lymphocyte , immunology , t cell , biology , genetics
Problem: We hypothesize that the normal immunologic responses by the maternal immune system during pregnancy are not as well‐regulated in gestational diabetes (GD) patients as in healthy pregnant women. Method of study: Using two‐color flow cytometry we evaluated frequencies of peripheral blood lymphocytes in 20 GD patients being treated with insulin; 43 GD patients treated with dietary therapy but no insulin; 44 women experiencing normal pregnancies; and 48 non‐pregnant women. Results: When compared with healthy pregnant women, both GD cohorts showed higher percentages CD4+CD25+ ( P < 0.05), CD4+CD45RO+ ( P < 0.05) and CD4+CD29+ ( P < 0.01) but lower percentages of CD4+CD45RA+ ( P < 0.05). Higher percentages of the activated phenotypes CD8+CD25+ and CD8+HLA‐DR+ cells in the diet‐treated cohort and CD4+HLA‐DR+ cells in insulin‐treated GB cohort, were observed compared with healthy pregnant subjects ( P < 0.05). Conclusions: Expanded populations of activated peripheral blood T cells are associated with GD, suggesting that normal maternal immunosuppression is less effective in GD‐afflicted women.