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Antichlamydial and Antisperm Antibodies in Patients with Chlamydial Infections
Author(s) -
Dimitrova Dimitrina,
Kalaydjiev Svetoslav,
Hristov Lyubomir,
Nikolov Krasimir,
Boyadjiev Todor,
Nakov Lyudmil
Publication year - 2004
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2004.00230.x
Subject(s) - chlamydia trachomatis , sex organ , antibody , chlamydia , chlamydial infection , medicine , immunology , direct agglutination test , antigen , incidence (geometry) , chlamydiaceae , trachoma , chlamydiales , latex fixation test , biology , serology , pathology , genetics , physics , optics
Problem: Establishing the correlation between antichlamydial antibodies (AchAbs) and antisperm antibodies (ASA) in patients with chlamydial infections. Method of study: ASA were studied in sera from patients (142 with genital, 57 with ocular chlamydial infections) and control group ( n = 100) by gelatin and tray agglutination test (TAT), sperm immobilization test (SIT) and ELISA. AchAbs were revealed by ELISA. Results: A significantly higher ( P < 0.05) ASA incidence was noted in patients with genital infections as compared with controls and patients with ophthalmologic infection ( P < 0.0001), but not between patients with ophthalmologic infection and controls ( P > 0.05). A significant correlation was established between AchAbs and ASA for TAT ( r = 0.8214, P = 0.0341), SIT ( r = 0.797, P = 0.032) and ELISA ( r = 0.8519, P = 0.0313) in patients with genital infections only. Conclusions: The genital Chlamydia infection may play a role in the induction of ASA. This is probably a result of the inflammatory process, but not of cross‐reactivity between sperm and Chlamydia trachomatis antigens.