Premium
Interleukin‐4 Gene Polymorphism is not Involved in the Risk of Recurrent Pregnancy Loss
Author(s) -
Saijo Yasuaki,
Sata Fumihiro,
Yamada Hideto,
Konodo Tomoko,
Kato Emi Hirayama,
Kataoka Soromon,
Shimada Shigeki,
Morikawa Mamoru,
Minakami Hisanori,
Kishi Reiko
Publication year - 2004
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2004.00193.x
Subject(s) - genotype , odds ratio , allele , pregnancy , biology , variable number tandem repeat , abortion , genetics , polymorphism (computer science) , gene , immunology , cytokine , medicine
Problem: Enhanced secretion of type‐2 T‐helper (Th2) cytokine is a characteristic feature in normal physiological pregnancy. A study has demonstrated defective production of interleukine‐4 (IL‐4) and other Th2 cytokine in women with recurrent pregnancy loss (RPL). Several studies have suggested that IL‐4 variable number of tandem repeat (VNTR) gene polymorphism is probably associated with different IL‐4 production. Methods of study: The IL‐4 VNTR genotypes were assessed in 109 Japanese women with RPL and 210 ethnically matched women experiencing at least one live birth and no spontaneous abortion. Results: No significant differences in IL‐4 VNTR genotype frequencies were found between the RPL and the control [B1B1 genotype (reference); B1/B2 and B2/B2 genotypes, odds ratio, 0.91; 95% confidence interval, 0.58–1.45]. Conclusion: The present study suggests that the IL‐4 VNTR allele is not a major genetic regulator in RPL.