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Macrophages and Apoptotic Cell Clearance During Pregnancy
Author(s) -
Abrahams Vikki M.,
Kim Yeon Mee,
Straszewski Shawn L.,
Romero Roberto,
Mor Gil
Publication year - 2004
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.2004.00156.x
Subject(s) - apoptosis , decidua , pregnancy , macrophage , immune system , microbiology and biotechnology , biology , immunology , programmed cell death , cell , embryo , fetus , in vitro , placenta , genetics , biochemistry
Background: During implantation, apoptosis is critical for the appropriate tissue remodeling of the maternal decidua and invasion of the developing embryo, yet the regulation of apoptosis is also imperative for a successful pregnancy. The quick and effective removal of apoptotic cells by tissue macrophages represents an essential process, which prevents the release of self‐antigens, and in the case of pregnancy, paternal alloantigens. Methods of study: Recent studies have shown that the process of apoptotic cell clearance is not a neutral event, but rather an active one that induces macrophage production of anti‐inflammatory cytokines and survival factors. Apoptotic cell clearance is, therefore, necessary for the resolution of inflammatory conditions, which during pregnancy could have lethal consequences. Conclusions: The function of the maternal immune system during implantation and throughout pregnancy is, therefore, an important area of investigation. This review will discuss the role of decidual macrophages in apoptotic cell clearance during pregnancy.