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Effect of Neonatal Treatment with a GnRH Antagonist on Development of the Cell‐Mediated Immune Response in Marmosets
Author(s) -
Mann David R.,
Lunn Stephen F.,
Akinbami Mukaila A.,
Samuel Kay,
Waterfall Martin,
Fraser Hamish M.
Publication year - 1999
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1999.tb00482.x
Subject(s) - marmoset , immune system , endocrinology , medicine , biology , peripheral blood mononuclear cell , cellular immunity , cell growth , agonist , immunity , immunology , in vitro , receptor , paleontology , biochemistry , genetics
PROBLEM: We examined the effect of neonatal treatment with a gonadotropin‐releasing hormone (GnRH) antagonist (antide) on the development of cell‐mediated immunity in male marmosets. METHOD OF STUDY: Neonatal marmoset twins were treated with either vehicle or antide, and the proliferative response (PR) of lymphoid tissue to mitogens was assessed during infancy, the peripubertal period, and adulthood. RESULTS: Basal proliferation of peripheral blood mononuclear cells (PBMC) from treated peripubertal twins was elevated above control values, but the PR of the cells to T and B cell mitogens was subnormal. Conversely, PBMC from treated infants exhibited an enhanced PR to some of the mitogens employed. In vitro culturing of thymocytes (control or treated) from the three developmental stages with either antide or a GnRH agonist increased basal proliferation, but decreased the PR to mitogens by 60–80%. CONCLUSION: Neonatal treatment with antide alters development of, but does not permanently impair, cell‐mediated immunity in the marmoset. GnRH appears to modulate immune responses throughout development in the primate.