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Secretion of Interleukin‐2 from Unstimulated Peripheral Blood Mononuclear Cells Is a Possible Pathogenic Mechanism in Recurrent Abortion
Author(s) -
HAMAI YOKO,
FUJII TOMOYUKI,
KOZUMA SHIRO,
SHIBATA YOICHI,
TAKETANI YUJI
Publication year - 1998
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1998.tb00390.x
Subject(s) - peripheral blood mononuclear cell , abortion , medicine , secretion , peripheral blood , immunology , interleukin , interleukin 4 , interleukin 2 , endocrinology , pregnancy , cytokine , biology , in vitro , biochemistry , genetics
PROBLEM: The objective of this study was to evaluate the activated status of helper T cells in women with recurrent abortion. METHOD OF STUDY: The spontaneous secretion of interleukin (IL)‐2 from peripheral blood mononuclear cells (PBMCs) obtained from 12 women with primary partner‐specific recurrent abortion and 7 normal females and 10 normal males was measured. RESULTS: IL‐2 concentrations in medium conditioned with PBMCs from the recurrent abortion group were 1.44 ± 0.32 (mean ± standard deviation) U/ml, whereas those from the normal female and male groups were below the minimum detectable concentration. CONCLUSION: The fact that PBMCs from recurrent aborters spontaneously secrete IL‐2 suggests that helper T cells are activated in recurrent aborters.