How Might Pregnancy Immunize Against Breast Cancer? | Zendy

Botelho Fernando | Zendy; Clark David A. | Zendy

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How Might Pregnancy Immunize Against Breast Cancer?

Author(s) -

Botelho Fernando,

Clark David A.

Publication year - 1998

Publication title -

american journal of reproductive immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.071

H-Index - 97

eISSN - 1600-0897

pISSN - 1046-7408

DOI - 10.1111/j.1600-0897.1998.tb00365.x

Subject(s) - breast cancer , pregnancy , muc1 , medicine , immunology , cytolysis , cancer , antigen , fetus , cytotoxic t cell , major histocompatibility complex , human leukocyte antigen , oncology , vaccination , cancer research , biology , biochemistry , genetics , in vitro

PROBLEM: This study investigated how pregnancy might protect against breast cancer. METHOD OF STUDY: A critical review of the literature was done. RESULTS/CONCLUSIONS: Support for an active role in pregnancy immunizing against breast cancer comes from case studies demonstrating a reciprocal correlation between pregnancy and breast cancer as well as recent experiments supporting the fetal antigen hypothesis that confirms the presence of a tumor‐specific antigen, MUC1, on both fetal and breast cancer tissues. Multiparous women also generate anti‐MUC1 major histocompatibility complex‐restricted cytotoxic T cell cytolytic activity against MUC1‐bearing tumor cell lines. Careful investigation of the fetal antigen hypothesis and tolerogenic mechanisms may lead to effective vaccination protocols against breast cancer and other cancers.

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