Premium
Phenotypic Analysis of Adhesion Molecules in First‐Trimester Decidual Tissue From Chorion Villus Samples
Author(s) -
Haynes Mrk K.,
Wapner Rnald L.,
Jackson Lird G.,
Smith J. Bruce
Publication year - 1997
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1997.tb00322.x
Subject(s) - decidua , cytotrophoblast , decidualization , stromal cell , biology , trophoblast , cell adhesion molecule , microbiology and biotechnology , decidual cells , andrology , immunology , placenta , cancer research , pregnancy , medicine , fetus , genetics
PROBLEM: First‐trimester decidua contain CD56 bright /CD16 neg lymphocytes that phenotypically resemble a subset of peripheral blood natural killer (NK) cells. Factors controlling their localization to decidua are unknown, but they may relate to trophoblast invasion, endometrial decidualization, and adhesion molecule expression. METHOD OF STUDY: Ninety‐one chorion villous samples (CVS) were screened for the presence of decidua, and selected specimens were analyzed for the expression of adhesion molecule pairs using a panel of monoclonal antibodies. RESULTS: Lymphoid cells in CVS‐derived decidua expressed CD56, PECAM, intracellular adhesion molecule‐1 (ICAM‐1), and the integrins LFA‐1, αEβ7, and α4β1, and co‐receptors for these molecules were expressed by decidual stromal cells, invasive trophoblasts, and venule endothelium. Some endothelium expressed a cuboidal phenotype. CONCLUSIONS: The expression of complimentary pairs of adhesion molecules by maternal lymphoid cells and by either extravillous cytotrophoblast or decidual stromal cells supports the hypothesis that these cells interact within decidua. Also, both LFA‐1 and α4β1 may contribute to decidual localization of CD56 bright NK cells.