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Immunogenetic and Oncogenic Properties of Rat Trophoblast Cell Lines
Author(s) -
Kunz Heinz W.,
Yuan XiuJuan,
Salgar Shashikumar K.,
DixonMcCarthy Barbara,
Gill Thomas J.
Publication year - 1997
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1997.tb00292.x
Subject(s) - trophoblast , biology , major histocompatibility complex , placenta , antigen , flow cytometry , mhc class i , microbiology and biotechnology , immunology , genetics , fetus , pregnancy
PROBLEM: The nature of major histocompatibility complex (MHC) antigen expression on rat placentas, trophoblast cell lines, and tumors derived from trophoblast cells was explored. METHOD OF STUDY: Cytohistochemical and flow cytometric analysis and molecular techniques. RESULTS: MHC antigen expression and genomic imprinting on the placenta and on trophoblast cells varies with the time of gestation and with the type of MHC antigen. CONCLUSIONS: There is no correlation in trophoblast cells between class I expression and cell ploidy, on the one hand, and malignant potential, on the other hand. Genomic imprinting of class I antigens in the rat placenta is a quantitative phenomenon.