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Evidence for an Elevation in Serum Interleukin‐2 and Tumor Necrosis Factor‐α Levels Before the Clinical Manifestations of Preeclampsia
Author(s) -
Hamai Yoko,
Fujii Tomoyuki,
Yamashita Takahiro,
Nishina Hidenori,
Kozuma Shiro,
Mikami Yasuyo,
Taketani Yuji
Publication year - 1997
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1997.tb00281.x
Subject(s) - preeclampsia , tumor necrosis factor alpha , tumor necrosis factor α , medicine , elevation (ballistics) , interleukin , tumor necrosis factors , interleukin 6 , necrosis , pregnancy , cytokine , immunology , endocrinology , biology , engineering , structural engineering , genetics
PROBLEM: The purpose of this study is to clarify whether the disruption of immune regulation occurs in early pregnancy before the clinical manifestations of preeclampsia. METHOD OF STUDY: The serum concentrations of interleukin‐2 (IL‐2) and tumor necrosis factor‐α (TNF‐α) were determined by using enzyme‐linked immunoadsorbent assay (ELISA) in the first trimester of pregnancy in women who had preeclampsia develop after 28 weeks of pregnancy (preeclamptic group) and in women who completed pregnancy uneventfully (control group). RESULTS: Serum concentrations of both IL‐2 and TNF‐α in the first trimester of the preeclamptic group were significantly higher than those of the control group. CONCLUSIONS: That the perturbation of feto‐maternal immune regulation may precede the clinical manifestations of preeclampsia, which may be of relevance in the development of preeclampsia, is suggested.