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Pathogenetic Implication of Interleukin‐2 Expressed in Preeclamptic Decidual Tissues: A Possible Mechanism of Deranged Vasculature of the Placenta Associated with Preeclampsia
Author(s) -
Hamai Yoko,
Fujii Tomoyuki,
Yamashita Takahiro,
Kozuma Shiro,
Okai Takashi,
Taketani Yuji
Publication year - 1997
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1997.tb00280.x
Subject(s) - decidua , preeclampsia , placenta , angiogenesis , peripheral blood mononuclear cell , lymphokine , stromal cell , immunology , andrology , endocrinology , medicine , biology , immune system , pregnancy , fetus , in vitro , biochemistry , genetics
PROBLEM: The purpose of this study is to clarify whether IL‐2 expressed in the decidua in preeclampsia affects the angiogenesis of the placenta. METHOD OF STUDY: We investigated the angiogenic substances released from human trophoblasts obtained from early pregnancy that had been pretreated with either IL‐2, non‐activated lymphocytes from peripheral blood mononuclear cells (PBMCs), decidual lymphocytes, or these lymphocytes activated by lymphokine (LAK cells). Angiogenic activity was determined by evaluating the ability of growth‐promotion of cultured human microvascular endothelial cells (HMvECs) using MTT assay. RESULTS: Trophoblasts pretreated with IL‐2 or non‐activated lymphocytes, irrespective of their origin, released angiogenic factor similar to those without pretreatment. However, trophoblasts pretreated with LAK cells released less angiogenic factor compared with those without pretreatment. CONCLUSIONS: Interleukin‐2 (IL‐2) expressed in preeclamptic decidua might reduce the angiogenic substances arising from trophoblasts by inducing LAK cells from decidual lymphocytes, which might be relevant to deranged vasculature of the placenta, a characteristic histology in preeclampsia.