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Angiogenesis and the Expression of Vascular Endothelial Growth Factor in Endometrium and Placenta
Author(s) -
Torry Donald S.,
Torry Ronald J.
Publication year - 1997
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1997.tb00189.x
Subject(s) - angiogenesis , vascular endothelial growth factor , endometrium , vascular permeability , vasculogenesis , placentation , regulator , placenta , vascular endothelial growth factor c , biology , vascular endothelial growth factor a , growth factor , placental growth factor , vascular endothelial growth factor b , medicine , endocrinology , microbiology and biotechnology , vegf receptors , cancer research , stem cell , pregnancy , receptor , progenitor cell , fetus , biochemistry , genetics , gene
PROBLEM: The demand for increased angiogenesis and microvascular permeability during cyclical changes in the endometrium and during placentation raises the possibility that aberrations in these events could lead to suboptimal reproductive performance. However, relatively little is presently known regarding the regulation of vascular growth and permeability in these tissues. METHOD OF STUDY: This review of current literature focuses on the expression, regulation, and potential physiological effects of vascular endothelial growth factor (VEGF) within endometrial and placental tissue. RESULTS: Spatial and temporal expression of VEGF as well as its restricted specificity, essential role in vasculogenesis/angiogenesis, and ability to induce vascular permeability makes VEGF an attractive regulator of vascular growth and permeability in the endometrium and placenta. CONCLUSION: A better understanding of the production, regulation, and physiological responses of the vasculature to angiogenic growth factors may lead to new therapeutic strategies for reproductive disturbances secondary to vascular insufficiencies within the female reproductive tract.