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Histochemical Demonstration of Interleukin‐2 in Decidua Cells of Patients With Preeclampsia
Author(s) -
HARA NAONORI,
FUJII TOMOYUKI,
OKAI TAKASHI,
TAKETANI YUJI
Publication year - 1995
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1995.tb00918.x
Subject(s) - decidua , preeclampsia , immunohistochemistry , immune system , medicine , staining , andrology , pregnancy , endocrinology , obstetrics , placenta , immunology , biology , pathology , fetus , genetics
PROBLEM : The objective of this study was to gain insight into the immunological aspects of preeclampsia. METHOD : The presence of interleukin‐2 (IL‐2) protein in the decidua was examined in five preeclamptic patients and seven normal pregnant women employing the immunohistochemistry. RESULTS : The decidua cells were strongly stained for IL‐2 in four out of five preeclamptic patients, while only very weak, if any, staining was observed in all the uncomplicated pregnant women. CONCLUSIONS : IL‐2 was clearly present in decidua cells in the preeclamptic setting, suggesting the possible involvement of immune‐activation in the phathophysiology of preeclampsia.