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Lack of Magainin‐Like Activity in Human Cervical Tissue
Author(s) -
HANSEN KEITH A.,
KILIANSKI JOSEPH,
NEWHALL KATHY,
WRIGHT GEORGE,
STOCK RICHARD J.,
ARCHER DAVID
Publication year - 1995
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1995.tb00910.x
Subject(s) - magainin , cervix , polyclonal antibodies , biology , antimicrobial peptides , pathology , anatomy , antibody , chemistry , medicine , immunology , microbiology and biotechnology , antimicrobial , cancer
PROBLEM : The cervix plays an integral role in innate immunity of the human reproductive tract. Magainins are antimicrobial and spermicidal peptides recently described in human submandibular glands. We investigated the human cervix for magainin‐like peptides. METHOD : Histologic sections of frozen and paraffin embedded cervical tissue from nine subjects were separately incubated with two rabbit, polyclonal, anti‐magainin antibodies (CB‐2 and CB‐7) to investigate for magainin‐like activity in the human cervix. RESULTS : There was no specific staining of cervical columnar cells within the endocervical canal or in the endocervical crypts. Magainin‐like immunoreactivity in the human submandibular gland confirmed previous observations. CONCLUSION : Antigen related to magainin‐like peptides were not discovered in the human cervix.