Premium
T‐Cell Receptors Are Expressed but Down‐Regulated on Intradecidual T Lymphocytes
Author(s) -
MORII TAKESHI,
NISHIKAWA KIYOSHI,
SAITO SHIGERU,
ENOMOTO MASAHIRO,
ITO AYAKO,
KURAI NOBUO,
SHIMOYAMA TAKETO,
ICHIJO MOTOHIKO,
NARITA NOBUHIRO
Publication year - 1993
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1993.tb00830.x
Subject(s) - t cell receptor , cd3 , flow cytometry , biology , t cell , microbiology and biotechnology , receptor , antigen , t lymphocyte , immunology , immune system , cd8 , biochemistry
PROBLEM: Dietl et al. considered “intradecidual T cell tolerance towards fetal antigens” with their observation that intradecidual T cells lack immunohistochemically detectable amounts of T cell receptor (TCR) molecules while expressing normal amounts of CD3 molecules during early normal pregnancy. METHOD: To reevaluate these findings we examined the TCR and CD3 expression on intradecidual T cells using flow cytometry. CONCLUSIONS: In our study, all intradecidual CD3 + T cells expressed either TCR αβ or TCR γδ. However, the expression of the CD3/TCR complex on intradecidual T cells was down‐regulated. The level of CD3/TCR complex expression on intradecidual T cells was about two‐thirds of that on peripheralblood T cells. Further, the proportions of αβ + and γδ + cells in CD3 + cells did not significantly differ between decidua and peripheral blood.