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Serum Soluble Interleukin‐2 Receptor α Levels in Patients With Gynecologic Cancers: Early Effect of Surgery
Author(s) -
BARTON DESMOND P.J.,
BLANCHARD D. KAY,
MICHELININORRIS BEATRIZ,
ROBERTS WILLIAM S.,
HOFFMAN MITCHEL S.,
FIORICA JAMES V.,
NICOSIA SANTO V.,
CAVANAGH DENIS,
DJEU JULIE Y.
Publication year - 1993
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1993.tb00621.x
Subject(s) - medicine , ovarian cancer , cervical cancer , immunosuppression , interleukin 2 , gastroenterology , stage (stratigraphy) , alpha (finance) , cancer , receptor , gynecologic cancer , surgery , paleontology , construct validity , patient satisfaction , biology
PROBLEM: To determine the early effect of abdominal cytoreductive surgery on serum soluble interleukin‐2 receptor α (sIL‐2Rα) levels in patients with ovarian and cervical cancer, and to determine if the extent of cytoreduction correlated with the changes in serum sIL2Rα. METHOD: Thirty‐nine patients with gynecologic cancer had serum sIL‐2Rα measured by enzyme‐linked immunosorbent assay before abdominal cytoreductive surgery and once in the early postoperative period. RESULTS: Only patients with advanced epithelial ovarian cancer had elevated preoperative serum sIL‐2Rα levels. In 20 of 25 ovarian cancer cases (80%) and 10 of 14 cervical cancer cases (71.4%) the postoperative serum sIL‐2Rα levels exceeded the preoperative level ( P = .003 and P = .011, respectively). Overall, the mean postoperative serum sIL‐2Rα level was greater than the preoperative level ( P = .0001). CONCLUSION: Patients with early stage gynecologic cancer did not have elevated serum sIL‐2Rα levels before surgery. In the early postoperative period the serum sIL‐2Rα level was increased, which may be a nonspecific response to the trauma of surgery. Soluble IL‐2Rα may be one of the factors responsible for the immunosuppression in the early postoperative period, but may also herald a surge of activated T cells.