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Hormonal Regulation of the Secretory IgA (sIgA) System: Estradiol‐ and Progesterone‐induced Changes in sIgA in Parotid Saliva Along the Menstrual Cycle
Author(s) -
GÓMEZ ENRIQUE,
ORTIZ VÍCTOR,
SAINTMARTIN BLANCA,
BOECK LOURDES,
DÍAZSÁNCHEZ VICENTE,
BOURGES HÉCTOR
Publication year - 1993
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1993.tb00590.x
Subject(s) - saliva , luteal phase , endocrinology , medicine , menstrual cycle , immunoglobulin a , follicular phase , hormone , secretory iga , parotid gland , antibody , immunoglobulin g , immunology , dentistry
The effect of estradiol (E 2 ) and progesterone (P 4 ) on the IgA system, both at the systemic and at the mucosal level, was studied in 10 healthy young adult Mexican women during two consecutive menstrual cycles (MC); the control group consisted of five young adult Mexican men. Eight matched samples of blood and parotid saliva were obtained, in which serum E 2 , P 4 , and IgA were quantified. Parotid saliva was obtained with Curby's device and sIgA was quantified by an ELISA method. The MC was divided into follicular phase (FP, days 1 to 16) and luteal phase (LP, days 17 to 30). Serum IgA showed slight fluctuations along the period of study, but they were not different between women and men. Irrespective of the phase of the MC, salivary sIgA was higher in women than in men ( P <0.01); sIgA was slightly but not significantly higher in the FP, as compared to the LP. The comparison of phases in each individual woman showed significantly higher levels in the FP (P<0.01). The profile of sIgA in saliva observed in women resembled the pattern of serum E 2 (r = 0.859, P<0.05), suggesting a possible relation of E 2 in the secretion of sIgA by the parotid gland.