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A Study of Early Pregnancy Factor Activity in the Sera of Patients With Unexplained Spontaneous Abortion
Author(s) -
SHUXIN HU,
ZHENQUN ZHENG
Publication year - 1993
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1993.tb00569.x
Subject(s) - abortion , gestation , pregnancy , titer , medicine , gynecology , early pregnancy factor , obstetrics , fetus , embryo , biology , antibody , immunology , microbiology and biotechnology , genetics
PROBLEM: Seventy‐seven sera samples obtained from 51 patients (6–20 wk gestation) with unexplained spontaneous abortions including 20 threatened abortions (TA), 13 inevitable abortions (IA), and 18 intrauterine fetal growth retardation (IFGR), as well as 9 sera from 9 patients (6–20 wk gestation) with hydatidiform mole (HM), were detected for early pregnancy factor (EPF) by rosette inhibition assay. Rosette inhibition titer (RIT) was used to express EPF activity. RESULTS: The RIT value of EPF was 5.95 ± 0.69(mean ± SD) in the TA group; 4.06 ± 0.93 in the IA group; 3.50 ± 0.71 in the IFGR group, and 4.00 ± 0.71 in the HM group. Except for the TA group, in which the mean RIT was in normal pregnancy range, the RIT in the other three groups was significantly lower ( P < 0.01) then that of the normal pregnancy group (5.81 ± 0.68). CONCLUSIONS: These results suggest that measurement of EPF is a sensitive method for judging survival of the embryo. It may be used to predict the prognosis of the patient with unexplained spontaneous abortion.