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Cytokines Considered Critical in Pregnancy
Author(s) -
HILL JOSEPH A.
Publication year - 1992
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1992.tb00772.x
Subject(s) - pregnancy , medicine , andrology , obstetrics , biology , genetics
Cytokines considered critical in pregnancy include interleukin‐1 (IL‐1), tumor necrosis factor alpha (TNF‐α), interferon gamma (IFN‐γ, granulocyte‐macrophage colony stimulating factor (GM‐CSF), and colony stimulating factor (CSF‐1). They affect blastocyst attachment, trophoblast outgrowth, implantation, proliferation of cells isolated from placentas, proliferation of trophoblast cell lines, and percent fetal resorption in spontaneously aborting mice. Cytokines also affect chorionic gonadotrophin and progesterone production by trophoblast. Cytokine effects vary with concentration, route of administration, and timing of secretion.