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Trophoblast Immunity in Human Pregnancy Defined by Antiidiotype
Author(s) -
TORRY DONALD S.,
FAULK W. PAGE,
MCINTYRE JOHN A.
Publication year - 1991
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1991.tb01091.x
Subject(s) - trophoblast , pregnancy , antigen , immunity , immunology , reproduction , antibody , immunization , idiotype , biology , medicine , immune system , fetus , placenta , genetics , monoclonal antibody
Successful reproduction in mammals requires the mother to immunologically accept genetically disparate tissues. Allotypic trophoblast antigens (TLX) are thought to be responsible for influencing maternal acceptance of the feto‐placental graft, and faulty regulation of immunity to TLX antigens has been associated with recurrent pregnancy losses. In this report, rabbit antiidiotype (RAb2) was produced to a human TLX antibody (Ab1). This RAb2 detected TLX cross‐reactive idio‐types (CRI) on antitrophoblast IgG from women with normal and abnormal pregnancies. These findings support an hypothesis that women respond immunologically to allotypic trophoblast antigens, and that idiotype‐antiidiotype regulation of this response is characteristic of normal pregnancy.