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Cytokines: An Overview
Author(s) -
TROTTA PAUL P.
Publication year - 1991
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1991.tb01082.x
Subject(s) - biological activity , biology , receptor , recombinant dna , intracellular , proinflammatory cytokine , cytokine , cell surface receptor , biochemistry , microbiology and biotechnology , immunology , in vitro , inflammation , gene
Cytokines are a broad, heterogeneous group of proteins and polypeptides that regulate intercellular communication. Examples of cytokines include interleukins, interferons, colony‐stimulating factors, and a variety of growth factors. The preparation of large quantities of highly purified recombinant cytokines has provided a basis for their biological and physicochemical characterization. The pleiotropic biological effects of these factors are expressed through binding to specific, high‐affinity cell‐surface receptors. Although they are different in amino acid sequence, cytokines have a number of biological and physicochemical properties in common.