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Long‐Term Follow‐up of Children Born to Women Immunized With Tetanus Toxoid During Pregnancy
Author(s) -
GILL THOMAS J.,
KARASIC RAYMOND B.,
ANTONCIC JANET,
RABIN BRUCE S.
Publication year - 1991
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1991.tb01065.x
Subject(s) - toxoid , tetanus , immunization , medicine , booster dose , immunology , transplacental , pregnancy , antibody , vaccination , fetus , biology , placenta , genetics
Ten years after transplacental immunization with tetanus toxoid, the antibody responses of the immunized children to a booster immunization with 5 Lf tetanus toxoid did not differ from those of the control children. The tetanus toxoid‐stimulated lymphocyte proliferative responses showed that there was no tolerance to tetanus toxoid induced by transplacental immunization, and the stimulation indices suggested that there may be some long‐term memory for tetanus toxoid among the T lymphocytes in children who had been transplacentally immunized by maternal immunization with a standard dose of tetanus toxoid.