Premium
HLA Antigen‐Sharing in Couples With Repeated Spontaneous Abortions and the Birthweight of Babies in Successful Pregnancies
Author(s) -
REZNIKOFFETIEVANT M.F.,
BONNEAU J.C.,
ALCALAY D.,
CAVELIER B.,
TOURÉ C.,
LOBET R.,
NETTER A.
Publication year - 1991
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1991.tb01059.x
Subject(s) - human leukocyte antigen , medicine , obstetrics , pregnancy , antigen , incidence (geometry) , immunology , biology , genetics , physics , optics
Previously, several groups reported an increase in HLA antigen‐sharing in couples suffering from unexplained repeated spontaneous abortions. It was felt necessary to find out if HLA sharing could have any effect on children born after a successful pregnancy. The birthweight figures of children of 76 couples with repeated spontaneous abortions were analyzed. The results show a significantly lower birthweight in babies born from those couples, presenting a high incidence of HLA antigen‐sharing, particularly concerning class II antigens.