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HLA‐DR and DQ Antigens and Anticardiolipin Antibodies in Women With Recurrent Spontaneous Abortions
Author(s) -
TRABACE SIMONETTA,
NICOTRA MARIA,
CAPPELLACCI SANDRA,
MORELLINI MARINA,
MUTTINELLI CLAUDIA,
SBRACIA MARCO,
PRIMA MARIA ANNA,
MASALA CESARE
Publication year - 1991
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1991.tb00715.x
Subject(s) - human leukocyte antigen , autoantibody , anticardiolipin antibodies , medicine , antigen , immunology , antibody , population , environmental health
IgG anticardiolipin antibodies (ACL) have been shown to occur in a high proportion of women with repeated unexplained miscarriages. Forty‐nine women with unexplained recurrent spontaneous abortions (RSA), previously assayed for the presence of ACL by an enzyme‐linked immunoabsorbent assay, were typed for HLA‐DR and DQ antigens by the classical microlymphocytotoxicity test. Twenty‐five women were positive for ACL and 24 were negative. HLA‐DR7 was found in 24.5% of 49 habitually aborting women vs. 28% of healthy controls; but the DR7 frequency was 40% in ACL positive patients vs. 8.3% in ACL negative patients (P = 0.011). These results show that in the Italian population an association between HLA‐DR7 antigen and ACL is present in women with unexplained RSA, suggesting that HLA‐DR genes might control the susceptibility to specific autoantibody production.