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The Effect of a Progesterone‐Induced Immunologic Blocking Factor on NK‐Mediated Resorption
Author(s) -
SZEKERESBARTHO JULIA,
KINSKY R.,
CHAOUAT G.
Publication year - 1990
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.1600-0897.1990.tb01047.x
Subject(s) - spleen , endocrinology , medicine , resorption , in vivo , blocking (statistics) , pregnancy , chemistry , fetus , biology , statistics , microbiology and biotechnology , mathematics , genetics
Transfer of spleen cells from poly (I)‐poly(C12U)‐treated Balb/c mice to 6.5‐days‐preg‐nant Balb/c mice significantly increased the resorption rate ( P <0.01) from 11% to 48%. The supernatant of progesterone‐treated spleen cells from pregnant C3H mice abrogated the effect of spleen cell transfer. We conclude that by blocking NK activity in vivo, the progesterone‐induced blocking factor favors the maintenance of pregnancy.